Dulaglutide Explained: Blood Sugar Control and Side Effects

Medically Reviewed By: Dr Jana Lim, Board-Accredited Family Physician

Board-Accredited Family Physician | MBChB, MMed (FM)

MBChB, MMed (FM) | Last updated: 12 Oct 2026

Found this page helpful?Helpful?

What Is Dulaglutide?

Dulaglutide is a once-weekly prescription injection from a group of medicines called GLP-1 receptor agonists, which work like a natural hormone that helps the body control blood sugar and appetite.

Liraglutide, semaglutide and tirzepatide act on the same hormone pathway.

For people who need extra support with their metabolic health, dulaglutide may be an option, particularly when diet and lifestyle changes alone have not achieved the desired results.

Dulaglutide Mechanism of Action: How Does It Work?

Dulaglutide helps maintain stable blood sugar levels and influences appetite through several effects:

1. Stimulates the pancreas to release insulin, but only when glucose levels are high.
2. Reduces glucagon release, a hormone that signals the liver to release stored sugar into the bloodstream.
3. Slows how quickly food moves from the stomach into the intestines (gastric emptying), extending feelings of fullness.
4. Stimulates GLP-1 receptors in the brain that control hunger, helping reduce calorie intake.

These combined actions help the body maintain more consistent glucose levels throughout the day.

Who Might Benefit from Dulaglutide?

Dulaglutide may be considered when:

• Lifestyle changes such as diet and exercise have provided insufficient metabolic improvement
• Other first-line options are contraindicated or have caused intolerable side effects
• There is a clinical need for once-weekly dosing to support adherence
• Your overall health profile suggests you may benefit from GLP-1 receptor activation

Dulaglutide is not suitable for everyone and requires a thorough medical evaluation before it can be prescribed.

“

"For patients who struggle with daily medication routines, a once-weekly injection can make a meaningful difference to consistency. I always emphasise that this works best as part of a broader approach that includes nutrition and activity."

Dr Jana Lim

What Are Potential Side Effects of Dulaglutide?

As with many other medications, side effects can occur with dulaglutide, particularly when starting treatment. Commonly reported issues include:

• Nausea, diarrhoea, vomiting, bloating, or stomach pain.
• Fatigue or low energy levels.
• Mild redness, swelling, or itching at the injection site.
• A slight increase in heart rate.

Most of these symptoms are temporary and tend to lessen as the body adjusts. However, seek urgent medical advice if you experience:

• Severe or persistent abdominal pain.
• Sudden upper stomach pain with nausea, which may suggest pancreatitis.
• Fever, yellowing of the eyes or skin, or pain under the ribs, which may indicate gallbladder problems.

Disclaimer: This list does not cover all possible side effects, so always speak with a doctor if you are unsure.

When Is Dulaglutide Not Recommended?

Dulaglutide is usually not recommended for:

• People with type 1 diabetes or diabetic ketoacidosis, as it relies on the body still producing insulin.
• Anyone with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, due to potential thyroid-related risks.
• Individuals with severe digestive conditions such as gastroparesis, since dulaglutide slows stomach emptying and may worsen these symptoms.

Where Can I Get Dulaglutide in Singapore?

Dulaglutide is a prescription-only medicine in Singapore and is not available over the counter.

A consultation with a doctor is required to determine suitability based on medical history and current health status. If prescribed, follow-up appointments allow for progress monitoring and adjustments to the treatment plan as needed.